Biochemistry, cellular and molecular biology
Biochemistry, cellular and molecular biology
Academic year 2023/2024
- Course ID
- Serena Marchio' (Lecturer)
Enrico Bracco (Lecturer)
Letizia Lanzetti (Lecturer)
Alberto Puliafito (Lecturer)
Guido Serini (Lecturer)
- 1st year
- Teaching period
- First semester
- Course disciplinary sector (SSD)
- BIO/10 - biochemistry
BIO/12 - clinical biochemistry and molecular biology
BIO/13 - experimental biology
- Formal authority
- Type of examination
Sommario del corso
This course encompasses several topics including (i) Introduction to Cellular and Molecular Biology, (ii) Cell Signaling, Metabolism, and Immunology, (iii) Modeling and Quantitative Approaches to Life Science, and (iv) Clinical Biochemistry. The primary objective of this course is to equip students with knowledge and understanding of the basic concepts of life science that are relevant to healthcare and biomedicine sectors, thereby fulfilling the main objective of the Master's degree. More specifically, the focus of this course is to provide students with broad knowledge of how life at the scale of molecules is connected to life at a much larger scales, from cells to organs and to illustrate with examples of the molecular mechanism of diseases, thereby giving students examples of how to implement computational and modeling approaches that describe the fundamental building blocks of living organisms.
Results of learning outcomes
By the end of the course, students will possess a broad knowledge of chemical and biological disciplines. They will be familiar with the fundamental building blocks of life and how these react in cells and regulate biocheemical reactions. They will be introduced to cell biology, how cells ilve, replicate, move, sense and defend themselves from hostile environments. They will be introduced to a set of major examples where biomolecules and their reactions are strictly connected to health and diseases. Such a set of notions will be contextualized in the different modules and integrated in order to give the studens a comprehensive and interdisciplinary view. Furthermore, a set of exmaples of theoretical modeling will be given. Finally, students will be able to confidently present their knowledge both verbally and in concise written statements by learning the technical terms pertinent to the different contexts and by organizing thoughts in an effective way.
The course will cover basic concepts in biochemistry, cellular and molecular biology. The sylllabus will include thee basics of preparatory biochemistry, fundamental metabolic and cellular biochemistry, cellular biology and computational and modeling approaches to life science.
The course is structured into 5 modules, which detailed syllabus can be found in the specific web pages:
A Structural biochemistry, or the molecules of life
B Introduction to cellular and molecular biology
C Cell Signaling, metabolism and introduction to immunology
D Modeling and quantitative approaches to life science
E Clinical biochemistry and molecular biology
All the lessons wll be done in presence. Explanations on the various topic will be provided to the class using slides as didactic material. The slides will be provided to the class in advance, so that students will be faclitated in following the lessons and in posing questions. At the end of each lesson, some time will be dedicated to recap te major arguments that have been discussed. Similarly, a rapid recap will be also done at te beginning of the following lessons to set the stage for the lesson helping the students to get into the topic. Particular attention will be devoted to cross-reference with other modules in order for the students to develop an interdisciplinary view of the content of the course.
Learning assessment methods
The exam is structured into two separate sections A and B. Particular attention will be devoted to integrate the different learning abilities, including knowledge and understanding, ability to apply knowledge and understanding and communication skills.
- Each module will end with a multiple choice question quiz in order for the student to evaluate her/his level of knowledge and understanding of the specific topics covered in the module. A weighted average (according to the fraction of CFU of each module) of the marks obtained in the final quiz of each module will account for a maximum total of 16 points. Should one or more modules be insufficient, the student will have to retake the module quiz or quizzes at the exam session.
- At the exam sessions students will have to present a written report (min 2 pages, max 3 pages) done by small groups (min 3 max 5 students) on a subject that can be selected among different topics proposed by the teachers of the course, in order to evaluate their ability to apply knowledge and understanding to a partially new context. Each group will be given a 20 min slot to present their work with a keynote presentation, where each member of the group will have to present a part of the work. The presentation will be followed by questions and discussion with the teachers and will account for maximum other 16 points.
Suggested readings and bibliography
- ONC0251A Structural biochemistry, or the molecules of life (ONC0251A)
- ONC0251B Introduction to cellular and molecular biology (ONC0251B)
- ONC0251C Cell Signaling, metabolism and introduction to immunology (ONC0251C)
- ONC0251D Modeling and quantitative approaches to life science (ONC0251D)
- ONC0251E Clinical biochemistry and molecular biology (ONC0251E)