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ONC0251E Clinical biochemistry and molecular biology


Clinical biochemistry and molecular biology


Academic year 2023/2024

Course ID
Guido Serini (Lecturer)
1st year
Teaching period
Course disciplinary sector (SSD)
BIO/12 - clinical biochemistry and molecular biology
Formal authority
Type of examination
Written and oral
Type of learning unit
Modular course
Biochemistry, cellular and molecular biology (ONC0251)

Sommario del corso


Course objectives

The primary aim of this module is to illustrate to students, through paradigmatic examples, how the knowledge gained by studying biochemical processes at the molecular, cellular, tissue, and organismal scales constitutes the key foundation for gaining the ultimate essence of the pathogenesis of human diseases. From a perspective of disease investigation methods, an emphasis will be given to genome-wide genetic analysis approaches that have enabled to identify genotype-phenotype associations and biochemical mechanisms underpinning a number of complex human diseases, as well as to translate this information into the clinical practice, both diagnostically and therapeutically.


Results of learning outcomes

By the end of the module, students will have mastered a broad understanding of how, by effectively realizing the paradigm from bench to bedside, molecular biochemical knowledge achieved by basic scientific research translates into the ability to understand the causative essence and develop protocols for the diagnosis and the therapy of human diseases.



  • Understanding the pathogenesis of complex human diseases: genome-wide genetic analysis and genotype-phenotype associations
  • The biochemistry and clinical molecular biology of atherosclerosis and coronary artery disease
  • The biochemistry and clinical molecular biology of diabetes mellitus
  • The biochemistry and clinical molecular biology of inflammatory bowel disease
  • The biochemistry and clinical molecular biology of some psychiatric diseases

Course delivery

The module will be organized in a typical series of face-to-face lectures. Students will be provided with the slides displayed in each lecture, as well as several of the relevant experimental papers and reviews concerning the topics that will be covered.


Learning assessment methods

The exam is structured into two separate sections A and B. Particular attention will be devoted to integrate the different learning abilities, including knowledge and understanding, ability to apply knowledge and understanding and communication skills. 

  • Each module will end with a multiple choice question quiz in order for the student to evaluate her/his level of knowledge and understanding of the specific topics covered in the module. A weighted average (according to the fraction of CFU of each module) of the marks obtained in the final quiz of each module will account for a maximum total of 16 points. Should one or more modules be insufficient, the student will have to retake the module quiz or quizzes at the exam session.
  • At the exam sessions students will have to present a written report (min 2 pages, max 3 pages) done by small groups (min 3 max 5 students) on a subject that can be selected among different topics proposed by the teachers of the course, in order to evaluate their ability to apply knowledge and understanding to a partially new context. Each group will be given a 20 min slot to present their work with a keynote presentation, where each member of the group will have to present a part of the work. The presentation will be followed by questions and discussion with the teachers and will account for maximum other 16 points.

Suggested readings and bibliography

Last update: 15/03/2024 13:59
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