Artificial Intelligence for Biomedicine and Healthcare

Selected research products

Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer
2023-01-01 Leto, Simonetta M; Ferri, Martina; Sassi, Francesco; Zanella, Eugenia R; Cottino, Francesca; Vurchio, Valentina; Catalano, Irene; Ferrero, Alessandro; Zingaretti, Caterina C; Marchiò, Caterina; Grassi, Elena; Trusolino, Livio; Bertotti, Andrea https://iris.unito.it/handle/2318/1898412

Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT)
2023-01-01 Marta Falcinelli , Giulia Dell’Omo, Elena Grassi , Elisa Mariella, Simonetta Maria Leto, Sharon Scardellato, Annalisa Lorenzato, Sabrina Arena , Andrea Bertotti, Livio Trusolino , Alberto Bardelli, https://iris.unito.it/handle/2318/1893657

A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells
2022-01-01 Russo, Mariangela; Pompei, Simone; Sogari, Alberto; Corigliano, Mattia; Crisafulli, Giovanni; Puliafito, Alberto; Lamba, Simona; Erriquez, Jessica; Bertotti, Andrea; Gherardi, Marco; Di Nicolantonio, Federica; Bardelli, Alberto; Cosentino Lagomarsino, Marco https://iris.unito.it/handle/2318/1869137

Effective drug combinations in breast, colon and pancreatic cancer cells
2022-01-01 Jaaks P.; Coker E.A.; Vis D.J.; Edwards O.; Carpenter E.F.; Leto S.M.; Dwane L.; Sassi F.; Lightfoot H.; Barthorpe S.; van der Meer D.; Yang W.; Beck A.; Mironenko T.; Hall C.; Hall J.; Mali I.; Richardson L.; Tolley C.; Morris J.; Thomas F.; Lleshi E.; Aben N.; Benes C.H.; Bertotti A.; Trusolino L.; Wessels L.; Garnett M.J. https://iris.unito.it/handle/2318/1848374

The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization
2022-01-01 Dudová, Zdenka; Conte, Nathalie; Mason, Jeremy; Stuchlík, Dalibor; Peša, Radim; Halmagyi, Csaba; Perova, Zinaida; Mosaku, Abayomi; Thorne, Ross; Follette, Alex; Pivarč, Ľuboslav; Šašinka, Radim; Usman, Muhammad; Neuhauser, Steven; Begley, Dale A; Krupke, Debra M; Frassà, Massimiliano; Fiori, Alessandro; Corsi, Riccardo; Vezzadini, Luca; Isella, Claudio; Bertotti, Andrea; Bult, Carol; Parkinson, Helen; Medico, Enzo; Meehan, Terrence; Křenek, Aleš https://iris.unito.it/handle/2318/1872223

Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin
2022-01-01 Tedesco, Martina; Giannese, Francesca; Lazarević, Dejan; Giansanti, Valentina; Rosano, Dalia; Monzani, Silvia; Catalano, Irene; Grassi, Elena; Zanella, Eugenia R; Botrugno, Oronza A; Morelli, Leonardo; Panina Bordignon, Paola; Caravagna, Giulio; Bertotti, Andrea; Martino, Gianvito; Aldrighetti, Luca; Pasqualato, Sebastiano; Trusolino, Livio; Cittaro, Davide; Tonon, Giovanni https://iris.unito.it/handle/2318/1869160

PhyliCS: a Python library to explore scCNA data and quantify spatial tumor heterogeneity
2021-01-01 Montemurro, Marilisa; Grassi, Elena; Pizzino, Carmelo Gabriele; Bertotti, Andrea; Ficarra, Elisa; Urgese, Gianvito https://iris.unito.it/handle/2318/1894596

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
2021-01-01 Woo, Xing Yi; Giordano, Jessica; Srivastava, Anuj; Zhao, Zi-Ming; Lloyd, Michael W.; de Bruijn, Roebi; Suh, Yun-Suhk; Patidar, Rajesh; Chen, Li; Scherer, Sandra; Bailey, Matthew H.; Yang, Chieh-Hsiang; Cortes-Sanchez, Emilio; Xi, Yuanxin; Wang, Jing; Wickramasinghe, Jayamanna; Kossenkov, Andrew V.; Rebecca, Vito W.; Sun, Hua; Mashl, R. Jay; Davies, Sherri R.; Jeon, Ryan; Frech, Christian; Randjelovic, Jelena; Rosains, Jacqueline; Galimi, Francesco; Bertotti, Andrea; Lafferty, Adam; O’Farrell, Alice C.; Modave, Elodie; Lambrechts, Diether; ter Brugge, Petra; Serra, Violeta; Marangoni, Elisabetta; El Botty, Rania; Kim, Hyunsoo; Kim, Jong-Il; Yang, Han-Kwang; Lee, Charles; Dean, Dennis A.; Davis-Dusenbery, Brandi; Evrard, Yvonne A.; Doroshow, James H.; Welm, Alana L.; Welm, Bryan E.; Lewis, Michael T.; Fang, Bingliang; Roth, Jack A.; Meric-Bernstam, Funda; Herlyn, Meenhard; Davies, Michael A.; Ding, Li; Li, Shunqiang; Govindan, Ramaswamy; Isella, Claudio; Moscow, Jeffrey A.; Trusolino, Livio; Byrne, Annette T.; Jonkers, Jos; Bult, Carol J.; Medico, Enzo; Chuang, Jeffrey H.; Giordano, Silvia; Corso, Simona; https://iris.unito.it/handle/2318/1768036

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
2021-01-01 Ponsioen B.; Post J.B.; Buissant des Amorie J.R.; Laskaris D.; van Ineveld R.L.; Kersten S.; Bertotti A.; Sassi F.; Sipieter F.; Cappe B.; Mertens S.; Verlaan-Klink I.; Boj S.F.; Vries R.G.J.; Rehmann H.; Vandenabeele P.; Riquet F.B.; Trusolino L.; Bos J.L.; Snippert H.J.G. https://iris.unito.it/handle/2318/1797853

Genome-wide CRISPR screens reveal Hippo pathway activation as a resistance mechanism in BRAF mutant colon cancer
2021-01-01 Brammeld, JS; Thorpe, H; Garcia, MA; Price, S; Young, J; Pfeifer, M; Lupo, B; Yusa, K; Trusolino, L; Garnett, M; Bertotti, A; Bakal, C; McDermott, U https://iris.unito.it/handle/2318/1885603

Synthetic lethality screening highlights colorectal cancer vulnerability to concomitant blockade of nedd8 and egfr pathways
2021-01-01 Invrea F.; Punzi S.; Petti C.; Minelli R.; Peoples M.D.; Bristow C.A.; Vurchio V.; Corrado A.; Bragoni A.; Marchio' C.; Bertotti A.; Trusolino L.; Bardelli A.; Isella C.; Carugo A.; Draetta G.F.; Medico E. https://iris.unito.it/handle/2318/1797885

Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer
2021-01-01 Lafferty, Adam; O'Farrell, Alice C; Migliardi, Giorgia; Khemka, Niraj; Lindner, Andreas U; Sassi, Francesco; Zanella, Eugenia R; Salvucci, Manuela; Vanderheyden, Evy; Modave, Elodie; Boeckx, Bram; Halang, Luise; Betge, Johannes; Ebert, Matthias P A; Dicker, Patrick; Argilés, Guillem; Tabernero, Josep; Dienstmann, Rodrigo; Medico, Enzo; Lambrechts, Diether; Bertotti, Andrea; Isella, Claudio; Trusolino, Livio; Prehn, Jochen H M; Byrne, Annette T https://iris.unito.it/handle/2318/1872224

Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer
2020-01-01 Lindner A.U.; Carberry S.; Monsefi N.; Barat A.; Salvucci M.; O'Byrne R.; Zanella E.R.; Cremona M.; Hennessy B.T.; Bertotti A.; Trusolino L.; Prehn J.H.M. https://iris.unito.it/handle/2318/1774807

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype
2020-01-01 Lupo, Barbara; Sassi, Francesco; Pinnelli, Marika; Galimi, Francesco; Zanella, Eugenia R.; Vurchio, Valentina; Migliardi, Giorgia; Gagliardi, Paolo Armando; Puliafito, Alberto; Manganaro, Daria; Luraghi, Paolo; Kragh, Michael; Pedersen, Mikkel W.; Horak, Ivan D.; Boccaccio, Carla; Medico, Enzo; Primo, Luca; Nichol, Daniel; Spiteri, Inmaculada; Heide, Timon; Vatsiou, Alexandra; Graham, Trevor A.; Élez, Elena; Argiles, Guillem; Nuciforo, Paolo; Sottoriva, Andrea; Dienstmann, Rodrigo; Pasini, Diego; Grassi, Elena; Isella, Claudio; Bertotti, Andrea; Trusolino, Livio https://iris.unito.it/handle/2318/1750197

EGFR blockade reverts resistance to KRAS G12C inhibition in colorectal cancer
2020-01-01 Amodio, Vito; Yaeger, Rona; Arcella, Pamela; Cancelliere, Carlotta; Lamba, Simona; Lorenzato, Annalisa; Arena, Sabrina; Montone, Monica; Mussolin, Benedetta; Bian, Yu; Whaley, Adele; Pinnelli, Marika; Murciano-Goroff, Yonina R; Vakiani, Efsevia; Valeri, Nicola; Liao, Wei-Li; Bhalkikar, Anuja; Thyparambil, Sheeno; Zhao, Hui-Yong; de Stanchina, Elisa; Marsoni, Silvia; Siena, Salvatore; Bertotti, Andrea; Trusolino, Livio; Li, Bob T; Rosen, Neal; Di Nicolantonio, Federica; Bardelli, Alberto; Misale, Sandra https://iris.unito.it/handle/2318/1740015

Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer
2020-01-01 Lorenzato, Annalisa; Magrì, Alessandro; Matafora, Vittoria; Audrito, Valentina; Arcella, Pamela; Lazzari, Luca; Montone, Monica; Lamba, Simona; Deaglio, Silvia; Siena, Salvatore; Bertotti, Andrea; Trusolino, Livio; Bachi, Angela; Di Nicolantonio, Federica; Bardelli, Alberto; Arena, Sabrina https://iris.unito.it/handle/2318/1738329

Implementing systems modelling and molecular imaging to predict the efficacy of BCL-2 inhibition in colorectal cancer patient-derived xenograft models
2020-01-01 O'Farrell A.C.; Jarzabek M.; Lindner A.U.; Carberry S.; Conroy E.; Miller I.S.; Connor K.; Shiels L.; Zanella E.R.; Lucantoni F.; Lafferty A.; White K.; Villamandos M.M.; Dicker P.; Gallagher W.M.; Keek S.A.; Sanduleanu S.; Lambin P.; Woodruff H.C.; Bertotti A.; Trusolino L.; Byrne A.T.; Prehn J.H.M. https://iris.unito.it/handle/2318/1774554

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga
2019-01-01 Catalano I.; Grassi E.; Bertotti A.; Trusolino L. https://iris.unito.it/handle/2318/1719281

One tool to find them all: A case of data integration and querying in a distributed LIMS platform
2019-01-01 Grand, Alberto; Geda, Emanuele; Mignone, Andrea; Bertotti, Andrea; Fiori, Alessandro* https://iris.unito.it/handle/2318/1694959

Evolving neoantigen profiles in colorectal cancers with DNA repair defects
2019-01-01 Rospo G.; Lorenzato A.; Amirouchene-Angelozzi N.; Magri A.; Cancelliere C.; Corti G.; Negrino C.; Amodio V.; Montone M.; Bartolini A.; Barault L.; Novara L.; Isella C.; Medico E.; Bertotti A.; Trusolino L.; Germano G.; Di Nicolantonio F.; Bardelli A. https://iris.unito.it/handle/2318/1709286

Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research
2019-01-01 Mignone A.; Grand A.; Fiori A.; Medico E.; Bertotti A. https://iris.unito.it/handle/2318/1709303

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases
2019-01-01 Beekhof R.; van Alphen C.; Henneman A.A.; Knol J.C.; Pham T.V.; Rolfs F.; Labots M.; Henneberry E.; Le Large T.Y.S.; de Haas R.R.; Piersma S.R.; Vurchio V.; Bertotti A.; Trusolino L.; Verheul H.M.W.; Jimenez C.R. https://iris.unito.it/handle/2318/1713251

Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models
2019-01-01 Belli, Valentina; Matrone, Nunzia; Napolitano, Stefania; Migliardi, Giorgia; Cottino, Francesca; Bertotti, Andrea; Trusolino, Livio; Martinelli, Erika; Morgillo, Floriana; Ciardiello, Davide; De Falco, Vincenzo; Giunta, Emilio Francesco; Bracale, Umberto; Ciardiello, Fortunato; Troiani, Teresa https://iris.unito.it/handle/2318/1713277

Adaptive mutability of colorectal cancers in response to targeted therapies
2019-01-01 Russo M.; Crisafulli G.; Sogari A.; Reilly N.M.; Arena S.; Lamba S.; Bartolini A.; Amodio V.; Magri A.; Novara L.; Sarotto I.; Nagel Z.D.; Piett C.G.; Amatu A.; Sartore-Bianchi A.; Siena S.; Bertotti A.; Trusolino L.; Corigliano M.; Gherardi M.; Lagomarsino M.C.; Di Nicolantonio F.; Bardelli A. https://iris.unito.it/handle/2318/1725664

Patient-derived xenografts and matched cell lines identify pharmacogenomic vulnerabilities in colorectal cancer
2019-01-01 Lazzari L.; Corti G.; Picco G.; Isella C.; Montone M.; Arcella P.; Durinikova E.; Zanella E.R.; Novara L.; Barbosa F.; Cassingena A.; Cancelliere C.; Medico E.; Sartore-Bianchi A.; Siena S.; Garnett M.J.; Bertotti A.; Trusolino L.; Di Nicolantonio F.; Linnebacher M.; Bardelli A.; Arena S. https://iris.unito.it/handle/2318/1715076

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
2019-01-01 Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ. https://iris.unito.it/handle/2318/1714058

LAS: A Bio-Clinical Integrated Laboratory Information System for Translational Data Management
2018-01-01 Fiori, Alessandro; Grand, Alberto; Geda, Emanuele; Schioppa, Domenico; Brundu, Francesco G.; Mignone, Andrea; Bertotti, Andrea https://iris.unito.it/handle/2318/1694957

A molecularly annotated model of patient-derived colon cancer stem-like cells to assess genetic and non-genetic mechanisms of resistance to anti-EGFR therapy
2018-01-01 Luraghi, Paolo; Bigatto, Viola; Cipriano, Elia; Reato, Gigliola; Orzan, Francesca; Sassi, Francesco; De Bacco, Francesca; Isella, Claudio; Bellomo, Sara Erika; Medico, Enzo; Comoglio, Paolo M; Bertotti, Andrea; Trusolino, Livio; Boccaccio, Carla https://iris.unito.it/handle/2318/1662775

Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts
2018-01-01 Simona Corso, Marilisa Cargnelutti, Stefania Durando, Silvia Menegon, Maria Apicella, Cristina Migliore, Tania Capeloa, Stefano Ughetto, Claudio Isella, Enzo Medico, Andrea Bertotti, Francesco Sassi, Ivana Sarotto, Laura Casorzo, Alberto Pisacane, Monica Mangioni, Antonino Sottile, Maurizio Degiuli, Uberto Fumagalli, Giovanni Sgroi, Sarah Molfino, Giovanni De Manzoni, Riccardo Rosati, Michele De Simone, Daniele Marrelli, Luca Saragoni, Stefano Rausei, Giovanni Pallabazzer, Franco Roviello, Paola Cassoni, Anna Sapino, Adam Bass, Silvia Giordano https://iris.unito.it/handle/2318/1664042

RET fusions in a small subset of advanced colorectal cancers at risk of being neglected
2018-01-01 Pietrantonio, F; Di Nicolantonio, F; Schrock, A B; Lee, J; Morano, F; Fucà, G; Nikolinakos, P; Drilon, A; Hechtman, J F; Christiansen, J; Gowen, K; Frampton, G M; Gasparini, P; Rossini, D; Gigliotti, C; Kim, S T; Prisciandaro, M; Hodgson, J; Zaniboni, A; Chiu, V K; Milione, M; Patel, R; Miller, V; Bardelli, A; Novara, L; Wang, L; Pupa, S; Sozzi, G; Ross, J; Di Bartolomeo, M; Bertotti, A; Ali, S; Trusolino, L; Falcone, A; de Braud, F; Cremolini, C https://iris.unito.it/handle/2318/1664543

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer
2018-01-01 Siravegna, Giulia; Lazzari, Luca; Crisafulli, Giovanni; Sartore-Bianchi, Andrea; Mussolin, Benedetta; Cassingena, Andrea; Martino, Cosimo; Lanman, Richard B.; Nagy, Rebecca J.; Fairclough, Stephen; Rospo, Giuseppe; Corti, Giorgio; Bartolini, Alice; Arcella, Pamela; Montone, Monica; Lodi, Francesca; Lorenzato, Annalisa; Vanzati, Alice; Valtorta, Emanuele; Cappello, Giovanni; Bertotti, Andrea; Lonardi, Sara; Zagonel, Vittorina; Leone, Francesco; Russo, Mariangela; Balsamo, Antonella; Truini, Mauro; Di Nicolantonio, Federica; Amatu, Alessio; Bonazzina, Erica; Ghezzi, Silvia; Regge, Daniele; Vanzulli, Angelo; Trusolino, Livio; Siena, Salvatore; Marsoni, Silvia; Bardelli, Alberto https://iris.unito.it/handle/2318/1675615

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
2017-01-01 Isella, Claudio; Brundu, Francesco; Bellomo, Sara E.; Galimi, Francesco; Zanella, Eugenia; Porporato, Roberta; Petti, Consalvo; Fiori, Alessandro; Orzan, Francesca; Senetta, Rebecca; Boccaccio, Carla; Ficarra, Elisa; Marchionni, Luigi; Trusolino, Livio; Medico, Enzo; Bertotti, Andrea https://iris.unito.it/handle/2318/1642129

Interrogating open issues in cancer precision medicine with patient-derived xenografts
2017-01-01 Byrne, Annette T; Alférez, Denis G.; Amant, Frédéric; Annibali, Daniela; Arribas, Joaquín; Biankin, Andrew V.; Bruna, Alejandra; Budinská, Eva; Caldas, Carlos; Chang, David K.; Clarke, Robert B.; Clevers, Hans; Coukos, George; Dangles-Marie, Virginie; Eckhardt, S. Gail; Gonzalez-Suarez, Eva; Hermans, Els; Hidalgo, Manuel; Jarzabek, Monika A.; de Jong, Steven; Jonkers, Jos; Kemper, Kristel; Lanfrancone, Luisa; Mælandsmo, Gunhild Mari; Marangoni, Elisabetta; Marine, Jean-Christophe; Medico, Enzo; Norum, Jens Henrik; Palmer, Héctor G.; Peeper, Daniel S.; Pelicci, Pier Giuseppe; Piris-Gimenez, Alejandro; Roman-Roman, Sergio; Rueda, Oscar M.; Seoane, Joan; Serra, Violeta; Soucek, Laura; Vanhecke, Dominique; Villanueva, Alberto; Vinolo, Emilie; Bertotti, Andrea; Trusolino, Livio https://iris.unito.it/handle/2318/1624823

Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer
2017-01-01 Picco, Gabriele; Petti, Consalvo; Sassi, Francesco; Grillone, Katia; Migliardi, Giorgia; Rossi, Teresa; Isella, Claudio; Di Nicolantonio, Federica; Sarotto, Ivana; Sapino, Anna; Bardelli, Alberto; Trusolino, Livio; Bertotti, Andrea; Medico, Enzo https://iris.unito.it/handle/2318/1618636

PDX-MI: Minimal information for patient-derived tumor xenograft models
2017-01-01 Meehan, Terrence F.; Conte, Nathalie; Goldstein, Theodore; Inghirami, Giorgio; Murakami, Mark A.; Brabetz, Sebastian; Zhiping, Gu; Wiser, Jeffrey A.; Dunn, Patrick; Begley, Dale A.; Krupke, Debra M.; Bertotti, Andrea; Bruna, Alejandra; Brush, Matthew H.; Byrne, Annette T.; Caldas, Carlos; Christie, Amanda L.; Clark, Dominic A.; Dowst, Heidi; Dry, Jonathan R.; Doroshow, James H.; Duchamp, Olivier; Evrard, Yvonne A.; Ferretti, Stephane; Frese, Kristopher K.; Goodwin, Neal C.; Greenawalt, Danielle; Haendel, Melissa A.; Hermans, Els; Houghton, Peter J.; Jonkers, Jos; Kemper, Kristel; Khor, Tin O.; Lewis, Michael T.; Lloyd, K. C. Kent; Mason, Jeremy; Medico, Enzo; Neuhauser, Steven B.; Olson, James M.; Peeper, Daniel S.; Rueda, Oscar M.; Seong, Je Kyung; Trusolino, Livio; Vinolo, Emilie; Wechsler-Reya, Robert J.; Weinstock, David M.; Welm, Alana; Weroha, S. John; Amant, Frã©dã©ric; Pfister, Stefan M.; Kool, Marcel; Parkinson, Helen; Butte, Atul J.; Bult, Carol J. https://iris.unito.it/handle/2318/1658615

Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals
2016-01-01 Lupo, Barbara; Vialard, Jorge; Sassi, Francesco; Angibaud, Patrick; Puliafito, Alberto; Pupo, Emanuela; Lanzetti, Letizia; Comoglio, Paolo M.; Bertotti, Andrea; Trusolino, Livio https://iris.unito.it/handle/2318/1559469

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations
2016-01-01 Arena, Sabrina; Siravegna, Giulia; Mussolin, Benedetta; Kearns, Jeffrey D.; Wolf, Beni B.; Misale, Sandra; Lazzari, Luca; Bertotti, Andrea; Trusolino, Livio; Adjei, Alex A.; Montagut, Clara; Di Nicolantonio, Federica; Nering, Rachel; Bardelli, Alberto https://iris.unito.it/handle/2318/1559473

A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors
2016-01-01 Gelfo, Valerio; Rodia, Maria Teresa; Pucci, Michela; Dall'Ora, Massimiliano; Santi, Spartaco; Solmi, Rossella; Roth, Lee; Lindzen, Moshit; Bonafè, Massimiliano; Bertotti, Andrea; Caramelli, Elisabetta; Lollini, Pier-Luigi; Trusolino, Livio; Yarden, Yosef; D'Uva, Gabriele; Lauriola, Mattia https://iris.unito.it/handle/2318/1615267

Lenalidomide normalizes tumor vessels in colorectal cancer improving chemotherapy activity
2016-01-01 Leuci, V.; Maione, F.; Rotolo, R.; Giraudo, E.; Sassi, F.; Migliardi, G.; Todorovic, M.; Gammaitoni, L.; Mesiano, G.; Giraudo, L.; Luraghi, P.; Leone, F.; Bussolino, F.; Grignani, G.; Aglietta, M.; Trusolino, L.; Bertotti, A.; Sangiolo, D. https://iris.unito.it/handle/2318/1579768

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial
2016-01-01 Sartore-Bianchi, Andrea; Trusolino, Livio*; Martino, Cosimo; Bencardino, Katia; Lonardi, Sara; Bergamo, Francesca; Zagonel, Vittorina; Leone, Francesco; Depetris, Ilaria; Martinelli, Erika; Troiani, Teresa; Ciardiello, Fortunato; Racca, Patrizia; Bertotti, Andrea; Siravegna, Giulia; Torri, Valter; Amatu, Alessio; Ghezzi, Silvia; Marrapese, Giovanna; Palmeri, Laura; Valtorta, Emanuele; Cassingena, Andrea; Lauricella, Calogero; Vanzulli, Angelo; Regge, Daniele; Veronese, Silvio; Comoglio, Paolo M.; Bardelli, Alberto*; Marsoni, Silvia*; Siena, Salvatore* (*Co-Senior Authors) https://iris.unito.it/handle/2318/1560696

Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas
2015-01-01 Leto, Simonetta M.; Sassi, Francesco; Catalano, Irene; Torri, Valter; Migliardi, Giorgia; Zanella, Eugenia R.; Throsby, Mark; Bertotti, Andrea; Trusolino, Livio https://iris.unito.it/handle/2318/1559135

A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells
2015-01-01 Picco, Gabriele; Petti, Consalvo; Trusolino, Livio; Bertotti, Andrea; Medico, Enzo https://iris.unito.it/handle/2318/1529850

HER2 Activating Mutations Are Targets for Colorectal Cancer Treatment
2015-01-01 Kavuri, Shyam M; Jain, Naveen; Galimi, Francesco; Cottino, Francesca; Leto, Simonetta M; Migliardi, Giorgia; Searleman, Adam C; Shen, Wei; Monsey, John; Trusolino, Livio; Jacobs, Samuel A; Bertotti, Andrea*; Bose, Ron* (*Corresponding Authors) https://iris.unito.it/handle/2318/1523247

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers
2015-01-01 Misale, Sandra; Bozic, Ivana; Tong, Jingshan; Peraza-Penton, Ashley; Lallo, Alice; Baldi, Federica; Lin, Kevin H.; Truini, Mauro; Trusolino, Livio; Bertotti, Andrea; Di Nicolantonio, Federica; Nowak, Martin A.; Zhang, Lin; Wood, Kris C.; Bardelli, Alberto https://iris.unito.it/handle/2318/1532747

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.
2015-01-01 Zanella ER;Galimi F;Sassi F;Migliardi G;Cottino F;Leto SM;Lupo B;Erriquez J;Isella C;Comoglio PM;Medico E;Tejpar S;Budinsk E;Trusolino L*;Bertotti A*(*Co-Senior e Corresponding Authors) https://iris.unito.it/handle/2318/1508351

Stromal contribution to the colorectal cancer transcriptome.
2015-01-01 Isella, C; Terrasi, A; Bellomo, Se; Petti, C; Galatola, G; Muratore, A; Mellano, A; Senetta, R; Cassenti, A; Sonetto, C; Inghirami, G; Trusolino, L; Fekete, Z; De Ridder, M; Cassoni, P; Storme, G; Bertotti, A; Medico, E. https://iris.unito.it/handle/2318/1508368

Derivation and charaterization of cancer initialling cells representative of metastatic colorectal cancer genetic heterogeneity
2015-01-01 V. Bigatto, P. Luraghi, E. Cipriano, G. _Reato, F.N.Orzan, R. Neggia, A. Bertotti, L. Trusolino, P.M.Comoglio, C. Boccaccio https://iris.unito.it/handle/2318/1708779

MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer
2015-01-01 García-García, Celina; Rivas, Martín A.; Ibrahim, Yasir H.; Calvo, María Teresa; Gris-Oliver, Albert; Rodríguez, Olga; Grueso, Judit; Antón, Pilar; Guzmán, Marta; Aura, Claudia; Nuciforo, Paolo; Jessen, Katti; Argilés, Guillem; Dienstmann, Rodrigo; Bertotti, Andrea; Trusolino, Livio; Matito, Judit; Vivancos, Ana; Chicote, Irene; Palmer, Héctor G.; Tabernero, Josep; Scaltriti, Maurizio; Baselga, José; Serra, Violeta https://iris.unito.it/handle/2318/1559118

The genomic landscape of response to EGFR blockade in colorectal cancer
2015-01-01 Bertotti, Andrea*; Papp, Eniko; Jones, Siân; Adleff, Vilmos; Anagnostou, Valsamo; Lupo, Barbara; Sausen, Mark; Phallen, Jillian; Hruban, Carolyn A.; Tokheim, Collin; Niknafs, Noushin; Nesselbush, Monica; Lytle, Karli; Sassi, Francesco; Cottino, Francesca; Migliardi, Giorgia; Zanella, Eugenia R.; Ribero, Dario; Russolillo, Nadia; Mellano, Alfredo; Muratore, Andrea; Paraluppi, Gianluca; Salizzoni, Mauro; Marsoni, Silvia; Kragh, Michael; Lantto, Johan; Cassingena, Andrea; Li, Qing Kay; Karchin, Rachel; Scharpf, Robert; Sartore-Bianchi, Andrea; Siena, Salvatore; Diaz, Luis A.; Trusolino, Livio*; Velculescu, Victor E*. (*Co-Senior e Corresponding Authors) https://iris.unito.it/handle/2318/1559157

Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugs.
2014-01-01 Pennacchietti S;Cazzanti M;Bertotti A;Rideout WM ;Han M;Gyuris J;Perera T;Comoglio PM;Trusolino L;Michieli P https://iris.unito.it/handle/2318/149419

Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3.
2014-01-01 Sun C;Hobor S;Bertotti A;Zecchin D;Huang S;Galimi F;Cottino F;Prahallad A;Grernrum W;Tzani A;Schlicker A;Wessels LF;Smit EF;Thunnissen E;Halonen P;Lieftink C;Beijersbergen RL;Di Nicolantonio F;Bardelli A;Trusolino L;Bernards R https://iris.unito.it/handle/2318/147879

MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients
2014-01-01 Rocci A;Gambella M;Aschero S;Baldi I;Trusolino L;Cavallo F;Gay F;Larocca A;Magarotto V;Omedè P;Isaia G;Bertotti A;Liberati AM;Catalano L;De Rosa L;Musto P;Vallone R;Falcone A;Drandi D;Ladetto M;Comoglio PM;Boccadoro M;Palumbo A https://iris.unito.it/handle/2318/143264

NOTCH3 SIGNALING REGULATES MUSASHI-1 EXPRESSION IN METASTATIC COLORECTAL CANCER CELLS.
2014-01-01 Pasto A;Serafin V;Pilotto G;Lago C;Bellio C;Trusolino L;Bertotti A;Hoey T;Plateroti M;Esposito G;Pinazza M;Agostini M;Nitti D;Amadori A;Indraccolo S https://iris.unito.it/handle/2318/147878

Cytokine-induced killer cells eradicate bone and soft-tissue sarcomas.
2014-01-01 Sangiolo D; Mesiano G; Gammaitoni L; Leuci V; Todorovic M; Giraudo L; Cammarata C; Dell'aglio C; D'Ambrosio L; Pisacane A; Sarotto I; Miano S; Ferrero I; Carnevale-Schianca F; Pignochino Y; Sassi F; Bertotti A; Piacibello W; Fagioli F; Aglietta M; Grignani G. https://iris.unito.it/handle/2318/141017

MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors.
2014-01-01 Luraghi P;Reato G;Cipriano E;Sassi F;Orzan F;Bigatto V;De Bacco F;Menietti E;Han M;Rideout WM;Perera T;Bertotti A;Trusolino L;Comoglio PM;Boccaccio C https://iris.unito.it/handle/2318/143265

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models.
2014-01-01 Peraldo-Neia C;Cavalloni G;Soster M;Gammaitoni L;Marchiò S;Sassi F;Trusolino L;Bertotti A;Medico E;Capussotti L;Aglietta M;Leone F https://iris.unito.it/handle/2318/153074

From Bench to Bedside: Does Preclinical Practice in Translational Oncology Need Some Rebuilding?
2013-01-01 A. Bertotti;L. Trusolino https://iris.unito.it/handle/2318/140395

Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer.
2013-01-01 Bardelli A*;Corso S*;Bertotti A*;Hobor S;Valtorta E;Siravegna G;Sartore-Bianchi A;Scala E;Cassingena A;Zecchin D;Apicella M;Migliardi G;Galimi F;Lauricella C;Zanon C;Perera T;Veronese S;Corti G;Amatu A;Gambacorta M;Diaz LA Jr;Sausen M;Velculescu VE;Comoglio P;Trusolino L;Di Nicolantonio F;Giordano S;Siena S (*Co-First Authors) https://iris.unito.it/handle/2318/134432

Animal research: Temper Italy's strict lab-animal law.
2013-01-01 Trusolino L;Bertotti A https://iris.unito.it/handle/2318/138936

MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases.
2013-01-01 Isella C;Mellano A;Galimi F;Petti C;Capussotti L;De Simone M;Bertotti A;Medico E;Muratore A https://iris.unito.it/handle/2318/143044

Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer.
2013-01-01 S. Gastaldi; F. Sassi; P. Accornero; D. Torti; F. Galimi; G. Migliardi; G. Molyneux; T. Perera; P. M. Comoglio; C. Boccaccio; M. J. Smalley; A. Bertotti*; L. Trusolino* (*Co-Senior Authors) https://iris.unito.it/handle/2318/102410

MET SIGNALING REGULATES GROWTH, REPOPULATING POTENTIAL AND BASAL CELL-FATE COMMITMENT OF MAMMARY LUMINAL PROGENITORS: IMPLICATIONS FOR BASAL-LIKE BREAST CANCER.
2012-01-01 Paolo Accornero; Stefania Gastaldi; Francesco Sassi; Davide Torti; Silvia Miretti; Eugenio Martignani; Mario Baratta; Matthew J Smalley; Andrea Bertotti; Livio Trusolino https://iris.unito.it/handle/2318/152889

Compensatory pathways in oncogenic kinase signaling and resistance to targeted therapies: Six degrees of separation
2012-01-01 Trusolino L; Bertotti A https://iris.unito.it/handle/2318/122160

LAS: A Software Platform to Support Oncological Data Management
2012-01-01 Baralis E; Bertotti A; Fiori A; Grand A. https://iris.unito.it/handle/2318/128964

A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors.
2012-01-01 D. Torti;F. Sassi;F. Galimi;S. Gastaldi;T. Perera;P. M. Comoglio;L. Trusolino*; A. Bertotti* (*Co-Senior Authors) https://iris.unito.it/handle/2318/102468

INHIBITION OF MEK AND PI3K/MTOR SUPPRESSES TUMOR GROWTH BUT DOES NOT CAUSE TUMOR REGRESSION IN PATIENT-DERIVED XENOGRAFTS OF RAS-MUTANT COLORECTAL CARCINOMAS
2012-01-01 Giorgia Migliardi; Francesco Sassi; Davide Torti; Francesco Galimi; Eugenia R. Zanella; Michela Buscarino; Dario Ribero; Andrea Muratore; Paolo Massucco; Alberto Pisacane; Mauro Risio; Lorenzo Capussotti; Silvia Marsoni; Federica Di Nicolantonio; Alberto Bardelli; Paolo M. Comoglio; Livio Trusolino*; Andrea Bertotti* (*Co-Senior Authors) https://iris.unito.it/handle/2318/107406

A molecularly annotated platform of patient-derived xenografts (‘xenopatients’) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer
2011-01-01 Bertotti A; Migliardi G; Galimi F; Sassi F; Torti D; Isella C; Corà D; Di Nicolantonio F; Buscarino M; Petti C; Ribero D; Russolillo N; Muratore A; Massucco P; Pisacane A; Molinaro L; Valtorta E; Sartore-Bianchi A; Risio M; Capussotti L; Gambacorta M; Siena S; Medico E; Sapino A; Marsoni S; Comoglio PM; Bardelli A†; Trusolino L† (†Co-Senior authors) https://iris.unito.it/handle/2318/96346

Genetic and expression analysis of MET, MACC1 and HGF in metastatic colorectal cancer: Response to Met inhibition in patient xenografts and pathological correlations
2011-01-01 Francesco Galimi; Davide Torti; Francesco Sassi; Claudio Isella; Davide Corà; Stefania Gastaldi; Dario Ribero; Andrea Muratore; Paolo Massucco; Dimitrios Siatis; Gianluca Paraluppi; Federica Gonella; Francesca Maione; Alberto Pisacane; Ezio David; Bruno Torchio; Mauro Risio; Mauro Salizzoni; Lorenzo Capussotti; Tim Perera; Enzo Medico; M.F. Di Renzo; Paolo M. Comoglio; Livio Trusolino*; Andrea Bertotti* (*Co-Senior Authors) https://iris.unito.it/handle/2318/110677

Met as a potential therapeutic target in basal-like breast cancer
2010-01-01 Gastaldi S; Bertotti A; Galimi F; Sassi F; Torti D; Smalley M; Trusolino L https://iris.unito.it/handle/2318/109458

EXPRESSION OF MET MRNA AS PROGNOSTIC MARKER IN MULTIPLE MYELOMA PATIENTS TREATED WITH NOVEL DRUGS
2010-01-01 Rocci A; Gambella M; Trusolino L; Gay F; Omedè P; Magarotto V; Bertotti A; Montefusco V; Crippa C; Patriarca F; Gilestro M; Liberati AM; Gaidano G; Di Raimondo F; Falcone A; Rossi G; Drandi D; Corradini P; Ladetto M; Comoglio PM; Boccadoro M; Palumbo A https://iris.unito.it/handle/2318/108336

Inhibition of Src impairs the growth of met-addicted gastric tumors.
2010-01-01 A. Bertotti;C. Bracco;F. Girolami;D. Torti;S. Gastaldi;F. Galimi;E. Medico;P. Elvin;P. M. Comoglio;L. Trusolino https://iris.unito.it/handle/2318/79609

Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice.
2010-01-01 Casazza A; Finisguerra V; Capparuccia L; Camperi A; Swiercz JM; Rizzolio S; Rolny C; Christensen C; Bertotti A; Sarotto I; Risio M; Trusolino L; Weitz J; Schneider M; Mazzone M; Comoglio PM; Tamagnone L. https://iris.unito.it/handle/2318/130565

The tetraspanin CD151 is required for met-dependent signaling and tumor cell growth
2010-01-01 Franco M; Muratori C; Corso S; Tenaglia E; Bertotti A; Capparuccia L; Trusolino L; Comoglio PM; Tamagnone L. https://iris.unito.it/handle/2318/82522

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition.
2010-01-01 S. Corso;E. Ghiso;V. Cepero;J. R. Sierra;C. Migliore;A. Bertotti;L. Trusolino;P. M. Comoglio;S. Giordano https://iris.unito.it/handle/2318/79783

Identification and pre-clinical validation of surrogate soluble biomarkers correlating with therapeutic response to met inhibition
2010-01-01 Torti D; Bertotti A; Galimi F; Gastaldi S; Sassi F; Trusolino L https://iris.unito.it/handle/2318/107490

MET signalling: principles and functions in development, organ regeneration and cancer.
2010-01-01 Trusolino L; Bertotti A; Comoglio PM https://iris.unito.it/handle/2318/78969

High Expression of mRNA and Gene Amplification of Met In Myeloma Plasma Cells Characterize a More Aggressive Disease
2010-01-01 Alberto Rocci; Manuela Gambella; Simona Aschero; Ileana Baldi; Livio Trusolino; Federica Cavallo; Alessandra Larocca; Paola Omedè; Andrea Bertotti; Vittorio Montefusco; Claudia Crippa; Francesca Patriarca; Anna Marina Liberati; Antonietta Falcone; Gianluca Isaia; Daniela Drandi; Marco Ladetto; Paolo M. Comoglio; Giovannino Ciccone; Mario Boccadoro; and Antonio Palumbo https://iris.unito.it/handle/2318/86884

met oncogene activation qualifies spontaneous canine osteosarcoma as a suitable pre-clinical model of human osteosarcoma
2009-01-01 Raffaella De Maria; Silvia Miretti; Selina Iussich; Martina Olivero;Emanuela Morello; Andrea Bertotti; James G. Christensen; Bartolomeo Biolatti; Roy A. Levine; Paolo Buracco; Maria Flavia Di Renzo https://iris.unito.it/handle/2318/64233

Met as a potential therapeutic target in basal-like breast cancer: An in vivo approach in a stem-cell perspective
2009-01-01 Gastaldi S; Bertotti A; Bracco C; Galimi F; Torti D; Trusolino L https://iris.unito.it/handle/2318/143340

Met oncogene activation qualifies spontaneous canine osteosarcoma as a suitable pre-clinical model of human osteosarcoma
2009-01-01 De Maria R; Miretti S; Iussich S; Olivero M; Morello E; Bertotti A; Christensen JG; Biolatti B; Levine RA; Buracco P; Di Renzo MF. https://iris.unito.it/handle/2318/57071

Only a subset of Met-activated pathways are required to sustain oncogene addiction
2009-01-01 Bertotti A; Burbridge MF; Gastaldi S; Galimi F; Torti D; Medico E; Giordano S; Corso S; Rolland-Valognes G; Lockhart BP; Hickman JA; Comoglio PM; Trusolino L. https://iris.unito.it/handle/2318/73352

Met Over-Expression Is a Prognostic Factor for Myeloma Patients Treated with Novel Agents
2009-01-01 Albero Rocci; Francesca Gay; Livio Trusolino; Paola Omedè; Andrea Bertotti; Vittorio Montefusco; Claudia Crippa; Francesca Patriarca; Milena Gilestro; Anna M. Liberati; Fausto Rossini; Tommaso Caravita; Antonietta Falcone; Giuseppe Rossi; Daniela Drandi; Paolo Corradini; Marco Ladetto; Paolo M. Comoglio; Mario Boccadoro; Antonio Palumbo https://iris.unito.it/handle/2318/71808

Met-driven invasive growth involves transcriptional regulation of Arhgap12
2008-01-01 Gentile A; D'Alessandro L; Lazzari L; Martinoglio B; Bertotti A; Mira A; Lanzetti L; Comoglio PM; Medico E. https://iris.unito.it/handle/2318/50909

beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis.
2005-01-01 Bertotti A; Comoglio PM; Trusolino L https://iris.unito.it/handle/2318/107484

Tyrosine kinase signal specificity: lessons from the HGF receptor.
2003-01-01 BERTOTTI A; PM COMOGLIO https://iris.unito.it/handle/2318/40912

A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth.
2001-01-01 L. TRUSOLINO; A. BERTOTTI; P.M. COMOGLIO https://iris.unito.it/handle/2318/110782

HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity
2000-01-01 L. TRUSOLINO; S. CAVASSA; P. ANGELINI; M. ANDO'; A. BERTOTTI; P. COMOGLIO; C. BOCCACCIO https://iris.unito.it/handle/2318/40794

Courses

• Anatomia umana ed Istologia (SCH0748)
  Corso di Laurea Magistrale in Odontoiatria e Protesi Dentaria
• ISTOLOGIA I (SCH0748C)
  Corso di Laurea Magistrale in Odontoiatria e Protesi Dentaria
• ISTOLOGIA II (SCH0748D)
  Corso di Laurea Magistrale in Odontoiatria e Protesi Dentaria
• Multi-omics and Data Science for Precision Medicine (ONC0260)
  Artificial Intelligence for Biomedicine and Healthcare
• ONC0260A Genomics, transcriptomics, and phenotypic screenings (ONC0260A)
  Artificial Intelligence for Biomedicine and Healthcare
• ONC0262B Cancer as a model system for population dynamics (ONC0262B)
  Artificial Intelligence for Biomedicine and Healthcare
• Systems Biomedicine Approaches to Epidemiology and public health (ONC0262)
  Artificial Intelligence for Biomedicine and Healthcare

Research topics

Andrea Bertotti has a scientific background in cancer biology, with a specific focus on receptor tyrosine kinase (RTK) signal transduction, oncogene addiction and targeted therapies.

As a Ph.D. student, he studied the biochemical mechanisms underlying the cooperation between RTKs and adhesion molecules during cancer progression. During his post-doc, he worked on identifying molecular traits associated with oncogene addiction, taking advantage of medium-to-large scale transcriptional and phosphoproteomic profiling approaches.

Starting 2008, he focused his research activity on more translational projects, with a particular interest in metastatic colorectal cancer. In particular, he initiated - and subsequently coordinated - a big effort aimed at generating a reliable preclinical platform for high-fidelity anticipation of clinical findings. This resulted in a collection of more than 800 liver metastases from colorectal carcinoma, which have been systematically transplanted in immunocompromised mice (patient-derived xenografts, PDXs), concomitantly profiled for molecular characteristics, and treated with approved or investigational compounds.

The informative potential of this platform, which constitutes a unique resource for translational studies in the field, led to studies that have been published in major scientific journals. A discovery with major clinical implications has been the finding that HER2 amplification predicts resistance to anti-EGFR antibodies and sensitivity to anti HER2 treatment, which recently entered the international guidelines for treatment of metastatic colorectal cancer.

More recently, thanks to an ERC Consolidator Grant funding (Grant N°724748), his research interests focused on the investigation of the molecular mechanisms sustaining drug tolerance and persistence of residual disease at maximal response to targeted therapies.

In particular, his studies focused on the identification of candidates for combination therapies with the goal of eradicating the residual disease in EGFR-dependent colorectal tumours treated with anti-EGFR blocking antibodies (i.e cetuximab). These studies resulted in a number of therapeutic approaches that have been validated in PDXs and are now considerated for the design of prospective clinical trials.

Moreover, he has been interested in deepening our understanding of the evolutionary properties of tumours, and in particolar of microsatellite stable colorectal cancer. To this aim, he is exploiting both commercial cancer cell lines and tumoroids derived from PDXs (Patient-derived tumoroids, PDTs) to study de mutation rate of colorectal tumours, both in basal conditions and under the selective pressure of targeted treatments.

Activities in agenda

See my calendar

Academic bodies

• Department Council - Department of Oncology

• Consiglio di Dipartimento - Dipartimento di Oncologia

• Docenti di riferimento a.a. 2022/2023

• Collegio Docenti